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Rac1/ROCK-driven membrane dynamics promote natural killer cell cytotoxicity via granzyme-induced necroptosis
BACKGROUND: Natural killer (NK) cells play an important role in cancer immunosurveillance and therapy. However, the target selectivity of NK cell activity is still poorly understood. RESULTS: Here, we used live-cell reporters to unravel differential epithelial cancer target killing by primary human...
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| Udgivet i: | BMC Biol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8323222/ https://ncbi.nlm.nih.gov/pubmed/34325694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-021-01068-3 |
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