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Further Investigations into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics

Thirty-six biscationic quaternary ammonium compounds were efficiently synthesized in one step to examine the effect of molecular geometry of two-carbon linkers on antimicrobial activity. The synthesized compounds showed strong antimicrobial activity against a panel of both Gram-positive and Gram-neg...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Leitgeb, Austin J., Feliciano, Javier A., Sanchez, Hugo A., Allen, Ryan A., Morrison, Kelly R., Sommers, Kyle J., Carden, Robert G., Wuest, William M., Minbiole, Kevin P. C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322965/
https://ncbi.nlm.nih.gov/pubmed/32022457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900662
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