A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering

Rheumatoid arthritis (RA) is exacerbated by TNF-alpha signaling. However, it remains unclear whether TNF-α-activated TNFR1 and TNFR2 are regulated by extracellular factors. Here, we showed that soluble glycosylated interleukin-17 receptor D (sIL-17RD), which was produced by proteolytic cleavage, enh...

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Bibliografiske detaljer
Udgivet i:Cell Mol Immunol
Main Authors: Liu, Sihan, Fu, Yanxia, Mei, Kunrong, Jiang, Yinan, Sun, Xiaojun, Wang, Yinyin, Ren, Fangli, Jiang, Congshan, Meng, Liesu, Lu, Shemin, Qin, Zhihai, Dong, Chen, Wang, Xinquan, Chang, Zhijie, Yang, Shigao
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322419/
https://ncbi.nlm.nih.gov/pubmed/32963355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-00548-w
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