Tumor Necrosis Factor Receptor 2 (TNFR2)·Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-κB Activation

TNF receptor 2 (TNFR2) exerts diverse roles in the pathogenesis of inflammatory and autoimmune diseases. Here, we report that TNFR2 but not TNFR1 forms a heteromer with interleukin-17 receptor D (IL-17RD), also named Sef, to activate NF-κB signaling. TNFR2 associates with IL-17RD, leading to mutual...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Yang, Shigao, Wang, Yinyin, Mei, Kunrong, Zhang, Sen, Sun, Xiaojun, Ren, Fangli, Liu, Sihan, Yang, Zi, Wang, Xinquan, Qin, Zhihai, Chang, Zhijie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294508/
https://ncbi.nlm.nih.gov/pubmed/25378394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586560
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