CD147 regulates antitumor CD8(+) T-cell responses to facilitate tumor-immune escape

Negative regulation of antitumor T-cell-immune responses facilitates tumor-immune escape. Here, we show that deletion of CD147, a type I transmembrane molecule, in T cells, strongly limits in vivo tumor growth of mouse melanoma and lung cancer in a CD8(+) T-cell-dependent manner. In mouse tumor mode...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Chen, Yatong, Xu, Jing, Wu, Xiaodong, Yao, Hui, Yan, Zhou, Guo, Ting, Wang, Wenjing, Wang, Peixiao, Li, Yu, Yang, Xiangmin, Li, Hao, Bian, Huijie, Chen, Zhi-Nan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322173/
https://ncbi.nlm.nih.gov/pubmed/33177695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-00570-y
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