APOBEC3-induced mutation of the hepatitis virus B DNA genome occurs during its viral RNA reverse transcription into (−)-DNA

APOBEC3s are innate single-stranded DNA cytidine-to-uridine deaminases that catalyze mutations in both pathogen and human genomes with significant roles in human disease. However, how APOBEC3s mutate a single-stranded DNA that is available momentarily during DNA transcription or replication in vivo...

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發表在:J Biol Chem
Main Authors: Chen, Zhigang, Eggerman, Thomas L., Bocharov, Alexander V., Baranova, Irina N., Vishnyakova, Tatyana G., Patterson, Amy P.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2021
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321922/
https://ncbi.nlm.nih.gov/pubmed/34181944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100889
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