Lactate and glutamine support NADPH generation in cancer cells under glucose deprived conditions

Although glucose, through pentose phosphate pathway (PPP), is the main source to generate NADPH, solid tumors are often deprived of glucose, hence alternative metabolic pathways to maintain NADPH homeostasis in cancer cells are required. Here, we report that lactate and glutamine support NADPH produ...

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Publicat a:Redox Biol
Autors principals: Ying, Minfeng, You, Duo, Zhu, Xiaobing, Cai, Limeng, Zeng, Siying, Hu, Xun
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321918/
https://ncbi.nlm.nih.gov/pubmed/34293554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.102065
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