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Enhanced epithelial sodium channel activity in neonatal Scnn1b mouse lung attenuates high oxygen-induced lung injury

Prolonged oxygen therapy leads to oxidative stress, epithelial dysfunction, and acute lung injury in preterm infants and adults. Heterozygous Scnn1b mice, which overexpress lung epithelial sodium channels (ENaC), and their wild-type (WT) C57Bl6 littermates were utilized to study the pathogenesis of...

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Vydáno v:Am J Physiol Lung Cell Mol Physiol
Hlavní autoři: Grant, Garett J., Mimche, Patrice N., Paine, Robert, Liou, Theodore G., Qian, Wei-Jun, Helms, My N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321857/
https://ncbi.nlm.nih.gov/pubmed/33949206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00538.2020
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