Hypoxia induces expression of angiotensin‐converting enzyme II in alveolar epithelial cells: Implications for the pathogenesis of acute lung injury in COVID‐19

SARS‐CoV‐2 uptake by lung epithelial cells is a critical step in the pathogenesis of COVID‐19. Viral entry is dependent on the binding of the viral spike protein to the angiotensin converting enzyme II protein (ACE2) on the host cell surface, followed by proteolytic cleavage by a host serine proteas...

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Vydáno v:Physiol Rep
Hlavní autoři: Sturrock, Anne, Zimmerman, Elizabeth, Helms, My, Liou, Theodore G., Paine, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8123561/
https://ncbi.nlm.nih.gov/pubmed/33991451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14854
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