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High-mobility group box-1 increases epithelial sodium channel activity and inflammation via the receptor for advanced glycation end products

Cystic fibrosis (CF) lung disease persists and remains life-limiting for many patients. Elevated high-mobility group box-1 protein (HMGB-1) levels and epithelial sodium channel hyperactivity (ENaC) are hallmark features of the CF lung. The objective of this study was to better understand the pathoge...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Grant, Garett J., Liou, Theodore G., Paine, Robert, Helms, My N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7099525/
https://ncbi.nlm.nih.gov/pubmed/31913693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00291.2019
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