BinomiRare: A robust test for association of a rare genetic variant with a binary outcome for mixed models and any case-control proportion

Whole-genome sequencing (WGS) and whole-exome sequencing studies have become increasingly available and are being used to identify rare genetic variants associated with health and disease outcomes. Investigators routinely use mixed models to account for genetic relatedness or other clustering variab...

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Vydáno v:HGG Adv
Hlavní autoři: Sofer, Tamar, Lee, Jiwon, Kurniansyah, Nuzulul, Jain, Deepti, Laurie, Cecelia A., Gogarten, Stephanie M., Conomos, Matthew P., Heavner, Ben, Hu, Yao, Kooperberg, Charles, Haessler, Jeffrey, Vasan, Ramachandran S., Cupples, L. Adrienne, Coombes, Brandon J., Seyerle, Amanda, Gharib, Sina A., Chen, Han, O’Connell, Jeffrey R., Zhang, Man, Gottlieb, Daniel J., Psaty, Bruce M., Longstreth, W.T., Rotter, Jerome I., Taylor, Kent D., Rich, Stephen S., Guo, Xiuqing, Boerwinkle, Eric, Morrison, Alanna C., Pankow, James S., Johnson, Andrew D., Pankratz, Nathan, Reiner, Alex P., Redline, Susan, Smith, Nicholas L., Rice, Kenneth M., Schifano, Elizabeth D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321319/
https://ncbi.nlm.nih.gov/pubmed/34337551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xhgg.2021.100040
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