BinomiRare: A robust test for association of a rare genetic variant with a binary outcome for mixed models and any case-control proportion

Whole-genome sequencing (WGS) and whole-exome sequencing studies have become increasingly available and are being used to identify rare genetic variants associated with health and disease outcomes. Investigators routinely use mixed models to account for genetic relatedness or other clustering variab...

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Veröffentlicht in:HGG Adv
Hauptverfasser: Sofer, Tamar, Lee, Jiwon, Kurniansyah, Nuzulul, Jain, Deepti, Laurie, Cecelia A., Gogarten, Stephanie M., Conomos, Matthew P., Heavner, Ben, Hu, Yao, Kooperberg, Charles, Haessler, Jeffrey, Vasan, Ramachandran S., Cupples, L. Adrienne, Coombes, Brandon J., Seyerle, Amanda, Gharib, Sina A., Chen, Han, O’Connell, Jeffrey R., Zhang, Man, Gottlieb, Daniel J., Psaty, Bruce M., Longstreth, W.T., Rotter, Jerome I., Taylor, Kent D., Rich, Stephen S., Guo, Xiuqing, Boerwinkle, Eric, Morrison, Alanna C., Pankow, James S., Johnson, Andrew D., Pankratz, Nathan, Reiner, Alex P., Redline, Susan, Smith, Nicholas L., Rice, Kenneth M., Schifano, Elizabeth D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321319/
https://ncbi.nlm.nih.gov/pubmed/34337551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xhgg.2021.100040
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