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Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8(+) T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation

The salivary gland is an important tissue for persistence and transmission of multiple viruses. Previous work showed that salivary gland tissue-resident CD8(+) T cells elicited by viruses were poorly functional ex vivo. Using a model of persistent murine cytomegalovirus (MCMV) infection, we now show...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Smith, Corinne J., Snyder, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320728/
https://ncbi.nlm.nih.gov/pubmed/34335618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.704862
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