CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice

α-Synuclein aggregation at the synapse is an early event in Parkinson’s disease and is associated with impaired striatal synaptic function and dopaminergic neuronal death. The cysteine string protein (CSPα) and α-synuclein have partially overlapping roles in maintaining synaptic function and mutatio...

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Vydáno v:Brain
Hlavní autoři: Caló, Laura, Hidari, Eric, Wegrzynowicz, Michal, Dalley, Jeffrey W, Schneider, Bernard L, Podgajna, Martyna, Anichtchik, Oleg, Carlson, Emma, Klenerman, David, Spillantini, Maria Grazia
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320296/
https://ncbi.nlm.nih.gov/pubmed/33760024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awab076
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