Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors

BACKGROUND: Modified vaccinia virus Ankara (MVA) are genetically engineered non-replicating viral vectors. Intratumoral administration of MVA induces a cyclic GMP-AMP synthase-mediated type I interferon (IFN) response and the production of high levels of the transgenes engineered into the viral geno...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Tenesaca, Shirley, Vasquez, Marcos, Alvarez, Maite, Otano, Itziar, Fernandez-Sendin, Myriam, Di Trani, Claudia Augusta, Ardaiz, Nuria, Gomar, Celia, Bella, Angela, Aranda, Fernando, Medina-Echeverz, José, Melero, Ignacio, Berraondo, Pedro
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2021
Témata:
Oncolytic and Local Immunotherapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320251/
https://ncbi.nlm.nih.gov/pubmed/34321273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001587
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