Insulin Fused to Apolipoprotein A-I Reduces Body Weight and Steatosis in DB/DB Mice

Background: Targeting long-lasting insulins to the liver may improve metabolic alterations that are not corrected with current insulin replacement therapies. However, insulin is only able to promote lipogenesis but not to block gluconeogenesis in the insulin-resistant liver, exacerbating liver steat...

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Udgivet i:Front Pharmacol
Main Authors: Ardaiz, Nuria, Gomar, Celia, Vasquez, Marcos, Tenesaca, Shirley, Fernandez-Sendin, Myriam, Di Trani, Claudia Augusta, Belsué, Virginia, Escalada, Javier, Werner, Ulrich, Tennagels, Norbert, Berraondo, Pedro
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934061/
https://ncbi.nlm.nih.gov/pubmed/33679386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.591293
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