N2E4, a Monoclonal Antibody Targeting Neuropilin-2, Inhibits Tumor Growth and Metastasis in Pancreatic Ductal Adenocarcinoma via Suppressing FAK/Erk/HIF-1α Signaling

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with extremely limited treatment; the effective targeting strategy stays an urgent unmet need. Neuropilin-2 (NRP2), a multifunctional transmembrane non-tyrosine-kinase glycoprotein, enhances various signal transduction pathway...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Wang, Li, Wang, Lanlan, Wang, Shengyu, Zhou, Zonglang, Liu, Zongjunlin, Xu, Peilan, Luo, Xian, Wu, Ting, Luo, Fanghong, Yan, Jianghua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8319910/
https://ncbi.nlm.nih.gov/pubmed/34336654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.657008
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