Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis

Voltage dependent anion channel 2 (VDAC2) is an outer mitochondrial membrane porin known to play a significant role in apoptosis and calcium signaling. Abnormalities in calcium homeostasis often leads to electrical and contractile dysfunction and can cause dilated cardiomyopathy and heart failure. H...

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Publicado no:Nat Commun
Main Authors: Shankar, Thirupura S., Ramadurai, Dinesh K. A., Steinhorst, Kira, Sommakia, Salah, Badolia, Rachit, Thodou Krokidi, Aspasia, Calder, Dallen, Navankasattusas, Sutip, Sander, Paulina, Kwon, Oh Sung, Aravamudhan, Aishwarya, Ling, Jing, Dendorfer, Andreas, Xie, Changmin, Kwon, Ohyun, Cheng, Emily H. Y., Whitehead, Kevin J., Gudermann, Thomas, Richardson, Russel S., Sachse, Frank B., Schredelseker, Johann, Spitzer, Kenneth W., Chaudhuri, Dipayan, Drakos, Stavros G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8319341/
https://ncbi.nlm.nih.gov/pubmed/34321484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24869-0
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