The antiarrhythmic compound efsevin directly modulates voltage‐dependent anion channel 2 by binding to its inner wall and enhancing mitochondrial Ca(2+) uptake

BACKGROUND AND PURPOSE: The synthetic compound efsevin was recently identified to suppress arrhythmogenesis in models of cardiac arrhythmia, making it a promising candidate for antiarrhythmic therapy. Its activity was shown to be dependent on the voltage‐dependent anion channel 2 (VDAC2) in the oute...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Wilting, Fabiola, Kopp, Robin, Gurnev, Philip A., Schedel, Anna, Dupper, Nathan J., Kwon, Ohyun, Nicke, Annette, Gudermann, Thomas, Schredelseker, Johann
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279994/
https://ncbi.nlm.nih.gov/pubmed/32059260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15022
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