Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity

Tightly regulated Ca(2+) homeostasis is a prerequisite for proper cardiac function. To dissect the regulatory network of cardiac Ca(2+) handling, we performed a chemical suppressor screen on zebrafish tremblor embryos, which suffer from Ca(2+) extrusion defects. Efsevin was identified based on its p...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Shimizu, Hirohito, Schredelseker, Johann, Huang, Jie, Lu, Kui, Naghdi, Shamim, Lu, Fei, Franklin, Sarah, Fiji, Hannah DG, Wang, Kevin, Zhu, Huanqi, Tian, Cheng, Lin, Billy, Nakano, Haruko, Ehrlich, Amy, Nakai, Junichi, Stieg, Adam Z, Gimzewski, James K, Nakano, Atsushi, Goldhaber, Joshua I, Vondriska, Thomas M, Hajnóczky, György, Kwon, Ohyun, Chen, Jau-Nian
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293673/
https://ncbi.nlm.nih.gov/pubmed/25588501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04801
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