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Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
Mitochondria are transported along microtubules by opposing kinesin and dynein motors. Kinesin-1 and dynein-dynactin are linked to mitochondria by TRAK proteins, but it is unclear how TRAKs coordinate these motors. We used single-molecule imaging of cell lysates to show that TRAK2 robustly activates...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8319186/ https://ncbi.nlm.nih.gov/pubmed/34321481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24862-7 |
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