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Kinetic Evidence for an Induced Fit Mechanism in the Binding of the Substrate Camphor by Cytochrome P450(cam)

Bacterial cytochrome P450 (P450) 101A1 (P450(cam)) has served as a prototype among the P450 enzymes and has high catalytic activity towards its cognate substrate, camphor. X-ray crystallography and NMR and IR spectroscopy have demonstrated the existence of multiple conformations of many P450s, inclu...

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Vydáno v:ACS Catal
Hlavní autoři: Guengerich, F. Peter, Child, Stella A., Barckhausen, Ian R., Goldfarb, Margo H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318206/
https://ncbi.nlm.nih.gov/pubmed/34327042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.0c04455
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