Strained contacts with the cell membrane may influence ligand affinity to G protein coupled receptors: a case of free fatty acid receptor 1 agonists

A set of 1,3,4-thiadiazole-2-carboxamides bearing a substituted biphenyl in the amide portion was synthesised and tested for agonistic activity towards free fatty acid receptor 1 (FFA1). The observed activity trends were impossible to rationalised based solely on the docking energy scores of Glide S...

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Vydáno v:J Enzyme Inhib Med Chem
Hlavní autoři: Lukin, Alexey, Bakholdina, Anna, Chudinov, Mikhail, Onopchenko, Oleksandra, Zhuravel, Elena, Zozulya, Sergey, Gureev, Maxim, Krasavin, Mikhail
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2021
Témata:
Short Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317940/
https://ncbi.nlm.nih.gov/pubmed/34294008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1955874
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