Estetrol Cotreatment of Androgen Deprivation Therapy in Infiltrating or Metastatic, Castration-sensitive Prostate Cancer: A Randomized, Double-blind, Phase II Trial (PCombi)

BACKGROUND: Androgen deprivation therapy (ADT) for prostate cancer with luteinizing hormone-releasing hormone (LHRH) agonists can be improved. OBJECTIVE: To assess safety, the frequency and severity of hot flushes (HFs), bone health, and antitumor effects of high-dose estetrol (HDE4) when combined w...

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Udgivet i:Eur Urol Open Sci
Main Authors: Coelingh Bennink, Herjan J.T., van Moorselaar, Jeroen A., Crawford, E. David, Roos, Erik P.M., Somford, Diederik M., Roeleveld, Ton A., de Haan, Tjard D., van Melick, Harm H.E., Reisman, Yacov, Zimmerman, Yvette, van Osta, Gonnie, Krijgh, Jan, Shore, Neal D., Saad, Fred, Schally, Andrew V., Debruyne, Frans M.J.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
Fag:
Prostate Cancer
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317802/
https://ncbi.nlm.nih.gov/pubmed/34337526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.euros.2021.04.005
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