Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans

Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan beyond FOXO remains unclear. Here, we profile IIS-dependent phosphorylation changes in a large-scale quantitative phosphoproteomic...

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Vydáno v:Nat Commun
Hlavní autoři: Li, Wen-Jun, Wang, Chen-Wei, Tao, Li, Yan, Yong-Hong, Zhang, Mei-Jun, Liu, Ze-Xian, Li, Yu-Xin, Zhao, Han-Qing, Li, Xue-Mei, He, Xian-Dong, Xue, Yu, Dong, Meng-Qiu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316574/
https://ncbi.nlm.nih.gov/pubmed/34315882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24816-z
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