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Gαq activation modulates autophagy by promoting mTORC1 signaling
The mTORC1 node plays a major role in autophagy modulation. We report a role of the ubiquitous Gαq subunit, a known transducer of plasma membrane G protein-coupled receptors signaling, as a core modulator of mTORC1 and autophagy. Cells lacking Gαq/11 display higher basal autophagy, enhanced autophag...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8316552/ https://ncbi.nlm.nih.gov/pubmed/34315875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24811-4 |
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