Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis

Activating mutations in the BRAF-MAPK pathway have been reported in histiocytoses, hematological inflammatory neoplasms characterized by multi-organ dissemination of pro-inflammatory myeloid cells. Here, we generate a humanized mouse model of transplantation of human hematopoietic stem and progenito...

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Publicado en:Nat Commun
Autores principales: Biavasco, Riccardo, Lettera, Emanuele, Giannetti, Kety, Gilioli, Diego, Beretta, Stefano, Conti, Anastasia, Scala, Serena, Cesana, Daniela, Gallina, Pierangela, Norelli, Margherita, Basso-Ricci, Luca, Bondanza, Attilio, Cavalli, Giulio, Ponzoni, Maurilio, Dagna, Lorenzo, Doglioni, Claudio, Aiuti, Alessandro, Merelli, Ivan, Di Micco, Raffaella, Montini, Eugenio
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316479/
https://ncbi.nlm.nih.gov/pubmed/34315896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24876-1
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