Retinoblastoma from human stem cell-derived retinal organoids

Retinoblastoma is a childhood cancer of the developing retina that initiates with biallelic inactivation of the RB1 gene. Children with germline mutations in RB1 have a high likelihood of developing retinoblastoma and other malignancies later in life. Genetically engineered mouse models of retinobla...

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Udgivet i:Nat Commun
Main Authors: Norrie, Jackie L., Nityanandam, Anjana, Lai, Karen, Chen, Xiang, Wilson, Matthew, Stewart, Elizabeth, Griffiths, Lyra, Jin, Hongjian, Wu, Gang, Orr, Brent, Tran, Quynh, Allen, Sariah, Reilly, Colleen, Zhou, Xin, Zhang, Jiakun, Newman, Kyle, Johnson, Dianna, Brennan, Rachel, Dyer, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316454/
https://ncbi.nlm.nih.gov/pubmed/34315877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24781-7
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