PHF19 inhibition as a therapeutic target in Multiple Myeloma

Epigenetic deregulation is increasingly recognized as a contributing pathological factor in multiple myeloma (MM). In particular tri-methylation of H3 lysine 27 (H3K27me3), which is catalyzed by PHD finger protein 19 (PHF19), a subunit of the Polycomb Repressive Complex 2 (PRC2), has recently shown...

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Publicado no:Curr Res Transl Med
Main Authors: Schinke, Carolina D., Bird, Jordan T., Qu, Pingping, Yaccoby, Shmuel, Lyzogubov, Valeriy V, Shelton, Randal, Ling, Wen, Boyle, Eileen M, Deshpande, Sharyu, Byrum, Stephanie D., Washam, Charity, Mackintosh, Samuel, Stephens, Owen, Thanendrarajan, Sharmilan, Zangari, Maurizio, Shaughnessy, John, Zhan, Fenghuang, Barlogie, Bart, van Rhee, Frits, Walker, Brian A
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316274/
https://ncbi.nlm.nih.gov/pubmed/33894670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.retram.2021.103290
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