Development and Validation of an In Silico Decision Tool To Guide Optimization of Intravenous Artesunate Dosing Regimens for Severe Falciparum Malaria Patients

Most deaths from severe falciparum malaria occur within 24 h of presentation to a hospital. Intravenous (i.v.) artesunate is the first-line treatment for severe falciparum malaria, but its efficacy may be compromised by delayed parasitological responses. In patients with severe malaria, the life-sav...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Zaloumis, Sophie G., Whyte, Jason M., Tarning, Joel, Krishna, Sanjeev, McCaw, James M., Cao, Pengxing, White, Michael T., Dini, Saber, Fowkes, Freya J. I., Maude, Richard J., Kremsner, Peter, Dondorp, Arjen, Price, Ric N., White, Nicholas J., Simpson, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316083/
https://ncbi.nlm.nih.gov/pubmed/33685888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02346-20
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