Development and Validation of an In Silico Decision Tool To Guide Optimization of Intravenous Artesunate Dosing Regimens for Severe Falciparum Malaria Patients

Most deaths from severe falciparum malaria occur within 24 h of presentation to a hospital. Intravenous (i.v.) artesunate is the first-line treatment for severe falciparum malaria, but its efficacy may be compromised by delayed parasitological responses. In patients with severe malaria, the life-sav...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Zaloumis, Sophie G., Whyte, Jason M., Tarning, Joel, Krishna, Sanjeev, McCaw, James M., Cao, Pengxing, White, Michael T., Dini, Saber, Fowkes, Freya J. I., Maude, Richard J., Kremsner, Peter, Dondorp, Arjen, Price, Ric N., White, Nicholas J., Simpson, Julie A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2021
Schlagworte:
Clinical Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316083/
https://ncbi.nlm.nih.gov/pubmed/33685888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02346-20
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