The Combination of Venetoclax and Ixazomib Selectively and Efficiently Kills HIV-Infected Cell Lines but Has Unacceptable Toxicity in Primary Cell Models

The antiapoptotic protein BCL2 inhibits death of HIV-infected cells. Previously, we showed that the BCL2 inhibitor venetoclax selectively kills acutely HIV-infected cells and reduces HIV DNA in latently infected CD4 T cells ex vivo after reactivation with anti-CD3/anti-CD28. However, there is a need...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Virol
Egile Nagusiak: Alto, Alecia, Natesampillai, Sekar, Chandrasekar, Aswath P., Krogman, Ashton, Misra, Anisha, Shweta, FNU, VanLith, Caitlin, Yao, Joseph D., Cummins, Nathan W., Badley, Andrew D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2021
Gaiak:
Vaccines and Antiviral Agents
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315902/
https://ncbi.nlm.nih.gov/pubmed/33827940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00138-21
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