Human cancers express TRAILshort, a dominant negative TRAIL splice variant, which impairs immune effector cell killing of tumor cells.

SECTION: Translational Cancer mechanisms and therapy. PURPOSE: TNF-related apoptosis inducing ligand (TRAIL) expression by immune cells contributes to anti-tumor immunity. A naturally occurring splice variant of TRAIL, called TRAILshort, antagonizes TRAIL-dependent cell killing. It is unknown whethe...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Aboulnasr, Fatma, Krogman, Ashton, Graham, Rondell P., Cummins, Nathan W., Misra, Anisha, Garcia-Rivera, Enrique, Anderson, Jeff R., Natesampillai, Sekar, Kogan, Nicole, Aravamudan, Murali, Nie, Zilin, Chung, Thomas D. Y., Buick, Richard, Feldman, Andrew L., King, Rebecca L., Novak, Anne J., Ansell, Stephen M., Kenderian, Saad, Badley, Andrew D.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642027/
https://ncbi.nlm.nih.gov/pubmed/32669373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-0251
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