Human cancers express TRAILshort, a dominant negative TRAIL splice variant, which impairs immune effector cell killing of tumor cells.

SECTION: Translational Cancer mechanisms and therapy. PURPOSE: TNF-related apoptosis inducing ligand (TRAIL) expression by immune cells contributes to anti-tumor immunity. A naturally occurring splice variant of TRAIL, called TRAILshort, antagonizes TRAIL-dependent cell killing. It is unknown whethe...

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Publicado en:Clin Cancer Res
Main Authors: Aboulnasr, Fatma, Krogman, Ashton, Graham, Rondell P., Cummins, Nathan W., Misra, Anisha, Garcia-Rivera, Enrique, Anderson, Jeff R., Natesampillai, Sekar, Kogan, Nicole, Aravamudan, Murali, Nie, Zilin, Chung, Thomas D. Y., Buick, Richard, Feldman, Andrew L., King, Rebecca L., Novak, Anne J., Ansell, Stephen M., Kenderian, Saad, Badley, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642027/
https://ncbi.nlm.nih.gov/pubmed/32669373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-0251
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