Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4(–)CD8(–)double negative (DN) thymocytes to generate αβ T cells in the thymus. However, how these signals ensure a high-fidelity proteome and safeguard the clonal diversification of the pre-selection TCR repertoir...

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Bibliographic Details
Published in:eLife
Main Authors: Liu, Xia, Yu, Jingjing, Xu, Longyong, Umphred-Wilson, Katharine, Peng, Fanglue, Ding, Yao, Barton, Brendan M, Lv, Xiangdong, Zhao, Michael Y, Sun, Shengyi, Hong, Yuning, Qi, Ling, Adoro, Stanley, Chen, Xi
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2021
Subjects:
Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315795/
https://ncbi.nlm.nih.gov/pubmed/34240701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.69975
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