Protein Quality Control Through Endoplasmic Reticulum-Associated Degradation Maintains Hematopoietic Stem Cell Identity and Niche Interactions

Stem cells need to be protected from genotoxic and proteotoxic stress to maintain a healthy pool throughout life(1–3). Little is known about the proteostasis mechanism that safeguards the stem cells. Here, we report Endoplasmic Reticulum-Associated Degradation (ERAD) as a protein quality checkpoint...

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Publicat a:Nat Cell Biol
Autors principals: Xu, Longyong, Liu, Xia, Peng, Fanglue, Zhang, Weijie, Zheng, Liting, Ding, Yao, Gu, Tianpeng, Lv, Kaosheng, Wang, Jin, Ortinau, Laura, Hu, Tianyuan, Shi, Xiangguo, Shi, Guojun, Shang, Ge, Sun, Shengyi, Iwawaki, Takao, Ji, Yewei, Li, Wei, Rosen, Jeffrey M., Zhang, Xiang H.-F., Park, Dongsu, Adoro, Stanley, Catic, Andre, Tong, Wei, Qi, Ling, Nakada, Daisuke, Chen, Xi
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888538/
https://ncbi.nlm.nih.gov/pubmed/32958856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-00581-x
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