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Protein Quality Control Through Endoplasmic Reticulum-Associated Degradation Maintains Hematopoietic Stem Cell Identity and Niche Interactions
Stem cells need to be protected from genotoxic and proteotoxic stress to maintain a healthy pool throughout life(1–3). Little is known about the proteostasis mechanism that safeguards the stem cells. Here, we report Endoplasmic Reticulum-Associated Degradation (ERAD) as a protein quality checkpoint...
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| Publicat a: | Nat Cell Biol |
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| Autors principals: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7888538/ https://ncbi.nlm.nih.gov/pubmed/32958856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-00581-x |
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