Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12

Bacterial genomes encode various multidrug efflux pumps (MDR) whose specific conditions for fitness advantage are unknown. We show that the efflux pump MdtEF-TolC, in Escherichia coli, confers a fitness advantage during exposure to extreme acid (pH 2). Our flow cytometry method revealed pH-dependent...

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Detalles Bibliográficos
Publicado en:Appl Environ Microbiol
Main Authors: Schaffner, Samantha H., Lee, Abigail V., Pham, Minh T. N., Kassaye, Beimnet B., Li, Haofan, Tallada, Sheetal, Lis, Cassandra, Lang, Mark, Liu, Yangyang, Ahmed, Nafeez, Galbraith, Logan G., Moore, Jeremy P., Bischof, Katarina M., Menke, Chelsea C., Slonczewski, Joan L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2021
Assuntos:
Genetics and Molecular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315180/
https://ncbi.nlm.nih.gov/pubmed/34085861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00724-21
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