Human Newborn Monocytes Demonstrate Distinct BCG-Induced Primary and Trained Innate Cytokine Production and Metabolic Activation In Vitro

BACKGROUND: Newborns exhibit distinct immune responses and are at high risk of infection. Neonatal immunization with BCG, the live attenuated vaccine against tuberculosis (TB), is associated with broad protection against a range of unrelated pathogens, possibly reflecting vaccine-induced training of...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Angelidou, Asimenia, Diray-Arce, Joann, Conti, Maria-Giulia, Netea, Mihai G., Blok, Bastiaan A., Liu, Mark, Sanchez-Schmitz, Guzman, Ozonoff, Al, van Haren, Simon D., Levy, Ofer
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315003/
https://ncbi.nlm.nih.gov/pubmed/34326836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.674334
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