Licensed Bacille Calmette-Guérin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation

BACKGROUND: Bacille Calmette-Guérin (BCG), the live attenuated tuberculosis vaccine, is manufactured under different conditions across the globe generating formulations that may differ in clinical efficacy. Innate immune recognition of live BCG contributes to immunogenicity suggesting that differenc...

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Angelidou, Asimenia, Conti, Maria-Giulia, Diray-Arce, Joann, Benn, Christine S., Shann, Frank, Netea, Mihai G., Liu, Mark, Potluri, Lakshmi Prasad, Sanchez-Schmitz, Guzman, Husson, Robert, Ozonoff, Al, Kampmann, Beate, van Haren, Simon Daniël, Levy, Ofer
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556328/
https://ncbi.nlm.nih.gov/pubmed/32005538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2019.11.060
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