Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer

T cell infiltration into tumors is essential for successful immunotherapy against solid tumors. Herein, we found that the expression of hyaluronic acid synthases (HAS) was negatively correlated with patient survival in multiple types of solid tumors including gastric cancer. HA impeded in vitro anti...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Zhao, Ruocong, Cui, Yuanbin, Zheng, Yongfang, Li, Shanglin, Lv, Jiang, Wu, Qiting, Long, Youguo, Wang, Suna, Yao, Yao, Wei, Wei, Yang, Jie, Wang, Bin-Chao, Zhang, Zhenfeng, Zeng, Hui, Li, Yangqiu, Li, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313856/
https://ncbi.nlm.nih.gov/pubmed/34326835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.660488
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