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Inhibition of PARP1 Dampens Pseudorabies Virus Infection through DNA Damage-Induced Antiviral Innate Immunity

Pseudorabies virus (PRV) is the causative pathogen of Aujeszky’s disease in pigs. Although vaccination is currently applied to prevent the morbidity of PRV infection, new applications are urgently needed to control this infectious disease. Poly(ADP-ribose) polymerase 1 (PARP1) functions in DNA damag...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Li, Guo-Li, Ding, Guang-Xu, Zeng, Lei, Ming, Sheng-Li, Fu, Peng-Fei, Wang, Qi, Yang, Guo-Yu, Wang, Jiang, Chu, Bei-Bei
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312877/
https://ncbi.nlm.nih.gov/pubmed/34037418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00760-21
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