Inhibition of PARP1 Dampens Pseudorabies Virus Infection through DNA Damage-Induced Antiviral Innate Immunity

Pseudorabies virus (PRV) is the causative pathogen of Aujeszky’s disease in pigs. Although vaccination is currently applied to prevent the morbidity of PRV infection, new applications are urgently needed to control this infectious disease. Poly(ADP-ribose) polymerase 1 (PARP1) functions in DNA damag...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Li, Guo-Li, Ding, Guang-Xu, Zeng, Lei, Ming, Sheng-Li, Fu, Peng-Fei, Wang, Qi, Yang, Guo-Yu, Wang, Jiang, Chu, Bei-Bei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312877/
https://ncbi.nlm.nih.gov/pubmed/34037418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00760-21
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