Deactivation blocks proton pathways in the mitochondrial complex I

Cellular respiration is powered by membrane-bound redox enzymes that convert chemical energy into an electrochemical proton gradient and drive the energy metabolism. By combining large-scale classical and quantum mechanical simulations with cryo-electron microscopy data, we resolve here molecular de...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Röpke, Michael, Riepl, Daniel, Saura, Patricia, Di Luca, Andrea, Mühlbauer, Max E., Jussupow, Alexander, Gamiz-Hernandez, Ana P., Kaila, Ville R. I.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307655/
https://ncbi.nlm.nih.gov/pubmed/34272275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019498118
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