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Deactivation blocks proton pathways in the mitochondrial complex I
Cellular respiration is powered by membrane-bound redox enzymes that convert chemical energy into an electrochemical proton gradient and drive the energy metabolism. By combining large-scale classical and quantum mechanical simulations with cryo-electron microscopy data, we resolve here molecular de...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8307655/ https://ncbi.nlm.nih.gov/pubmed/34272275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019498118 |
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