CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor

CD8(+) T cells are inherently cross-reactive and recognize numerous peptide antigens in the context of a given major histocompatibility complex class I (MHCI) molecule via the clonotypically expressed T cell receptor (TCR). The lineally expressed coreceptor CD8 interacts coordinately with MHCI at a...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Clement, Mathew, Knezevic, Lea, Dockree, Tamsin, McLaren, James E., Ladell, Kristin, Miners, Kelly L., Llewellyn-Lacey, Sian, Rubina, Anzelika, Francis, Ore, Cole, David K., Sewell, Andrew K., Bridgeman, John S., Price, David A., van den Berg, Hugo A., Wooldridge, Linda
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307375/
https://ncbi.nlm.nih.gov/pubmed/34272276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019639118
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