A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen

SIMPLE SUMMARY: The present study demonstrates that a radiolabeling strategy can positively modify hu5A10′s capacity to bind PSA and complex with the FcRn receptor, which results in a more homogenous activity distribution in tumors and enhanced therapy efficacy. These new innovative radiochemistry i...

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Bibliografiske detaljer
Udgivet i:	Cancers (Basel)
Main Authors:	Vilhelmsson Timmermand, Oskar, Örbom, Anders, Altai, Mohamed, Zedan, Wahed, Holmqvist, Bo, Safi, Marcella, Tran, Thuy A., Strand, Sven-Erik, Strand, Joanna
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI 2021
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC8307315/ https://ncbi.nlm.nih.gov/pubmed/34298682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13143469
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A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen

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