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A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen
SIMPLE SUMMARY: The present study demonstrates that a radiolabeling strategy can positively modify hu5A10′s capacity to bind PSA and complex with the FcRn receptor, which results in a more homogenous activity distribution in tumors and enhanced therapy efficacy. These new innovative radiochemistry i...
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| Publicado no: | Cancers (Basel) |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8307315/ https://ncbi.nlm.nih.gov/pubmed/34298682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13143469 |
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