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POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism

During embryonic development, hierarchical cascades of transcription factors interact with lineage-specific chromatin structures to control the sequential steps in the differentiation of specialized cell types. While examples of transcription factor cascades have been well documented, the mechanisms...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yu, Haoze V., Tao, Litao, Llamas, Juan, Wang, Xizi, Nguyen, John D., Trecek, Talon, Segil, Neil
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307294/
https://ncbi.nlm.nih.gov/pubmed/34266958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2105137118
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