Agelasine Diterpenoids and Cbl-b Inhibitory Ageliferins from the Coralline Demosponge Astrosclera willeyana

An extract of the coralline demosponge Astrosclera willeyana inhibited the ubiquitin ligase activity of the immunomodulatory protein Cbl-b. The bioassay-guided separation of the extract provided ten active compounds, including three new N-methyladenine-containing diterpenoids, agelasines W–Y (1–3),...

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Vydáno v:Mar Drugs
Hlavní autoři: Jiang, Wei, Wang, Dongdong, Wilson, Brice A. P., Kang, Unwoo, Bokesch, Heidi R., Smith, Emily A., Wamiru, Antony, Goncharova, Ekaterina I., Voeller, Donna, Lipkowitz, Stanley, O’Keefe, Barry R., Gustafson, Kirk R.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307156/
https://ncbi.nlm.nih.gov/pubmed/34202500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md19070361
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