Doxorubicin-Induced Fetal Mesangial Cell Death Occurs Independently of TRPC6 Channel Upregulation but Involves Mitochondrial Generation of Reactive Oxygen Species

Doxorubicin (DOX), a category D pregnancy drug, is a chemotherapeutic agent that has been shown in animal studies to induce fetal toxicity, including renal abnormalities. Upregulation of the transient receptor potential cation (TRPC) 6 channel is involved in DOX-induced podocyte apoptosis. We have p...

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Publicado en:Int J Mol Sci
Main Authors: Matthews, Anberitha T., Soni, Hitesh, Robinson-Freeman, Katherine E., John, Theresa A., Buddington, Randal K., Adebiyi, Adebowale
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8305841/
https://ncbi.nlm.nih.gov/pubmed/34299212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147589
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