Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors

The part of the influenza polymerase PA subunit featuring endonuclease activity is a target for anti-influenza therapies, including the FDA-approved drug Xofluza. A general feature of endonuclease inhibitors is their ability to chelate Mg(2+) or Mn(2+) ions located in the enzyme’s catalytic site. Pr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Reiberger, Robert, Radilová, Kateřina, Kráľ, Michal, Zima, Václav, Majer, Pavel, Brynda, Jiří, Dračínský, Martin, Konvalinka, Jan, Kožíšek, Milan, Machara, Aleš
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8305651/
https://ncbi.nlm.nih.gov/pubmed/34299354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147735
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados