PXR Modulates the Prostate Cancer Cell Response to Afatinib by Regulating the Expression of the Monocarboxylate Transporter SLC16A1

SIMPLE SUMMARY: Many kinase inhibitors have been tested as potential alternatives for the treatment of castration-resistant prostate cancers. However, none of these clinical trials led to drug approval despite interesting responses. Our study reveals that genes involved in drug metabolism and their...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Matheux, Alice, Gassiot, Matthieu, Fromont, Gaëlle, Leenhardt, Fanny, Boulahtouf, Abdelhay, Fabbrizio, Eric, Marchive, Candice, Garcin, Aurélie, Agherbi, Hanane, Combès, Eve, Evrard, Alexandre, Houédé, Nadine, Balaguer, Patrick, Gongora, Céline, Mbatchi, Litaty C., Pourquier, Philippe
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8305337/
https://ncbi.nlm.nih.gov/pubmed/34298852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13143635
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