Oncogenic Kinase Cascades Induce Molecular Mechanisms That Protect Leukemic Cell Models from Lethal Effects of De Novo dNTP Synthesis Inhibition

SIMPLE SUMMARY: Leukemic cells show differential sensitivity to apoptosis induction by the clinically relevant drug hydroxyurea. Since resistance to hydroxyurea can pose a therapeutic problem, we searched for mechanisms that protect such cells from the toxic effects of hydroxyurea. We used proteomic...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Pons, Miriam, Zeyn, Yanira, Zahn, Stella, Mahendrarajah, Nisintha, Page, Brent D. G., Gunning, Patrick T., Moriggl, Richard, Brenner, Walburgis, Butter, Falk, Krämer, Oliver H.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8304262/
https://ncbi.nlm.nih.gov/pubmed/34298678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13143464
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